Literature summary for 2.7.8.43 extracted from

Anandan, A.; Evans, G.L.; Condic-Jurkic, K.; OMara, M.L.; John, C.M.; Phillips, N.J.; Jarvis, G.A.; Wills, S.S.; Stubbs, K.A.; Moraes, I.; Kahler, C.M.; Vrielink, A.
Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding (2017), Proc. Natl. Acad. Sci. USA, 114, 2218-2223 .

Crystallization (Commentary)

Crystallization (Comment)	Organism
structure of full-length lipid A phosphoethanolamine transferase, determined to 2.75 A resolution. The structure reveals a helical membrane domain and a periplasmic facing soluble domain. The domains are linked by a helix that runs along the membrane surface interacting with the phospholipid head groups. Two helices located in a periplasmic loop between two transmembrane helices contain conserved charged residues and are implicated in substrate binding	Neisseria meningitidis serogroup B

Crystallization (Comment)

Organism

structure of full-length lipid A phosphoethanolamine transferase, determined to 2.75 A resolution. The structure reveals a helical membrane domain and a periplasmic facing soluble domain. The domains are linked by a helix that runs along the membrane surface interacting with the phospholipid head groups. Two helices located in a periplasmic loop between two transmembrane helices contain conserved charged residues and are implicated in substrate binding

Neisseria meningitidis serogroup B

Organism

Organism	UniProt	Comment	Textmining
Neisseria meningitidis serogroup B	Q7DD94	-	-
Neisseria meningitidis serogroup B MC58	Q7DD94	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant protein, purification in the presence of the detergent dodecyl-beta-D-maltoside	Neisseria meningitidis serogroup B

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-acyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycero-3-phosphoethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A	-	Neisseria meningitidis serogroup B	1-acyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A	-	?
1-acyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycero-3-phosphoethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A	-	Neisseria meningitidis serogroup B MC58	1-acyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A	-	?

Synonyms

Synonyms	Comment	Organism
EptA	-	Neisseria meningitidis serogroup B
NMB1638	-	Neisseria meningitidis serogroup B